Titanium nanosheet as robust and biosafe drug carrier for combined photochemo cancer therapy.

Abstract

Two-dimensional (2D) Titanium nanosheets (Ti NSs) have shown many excellent properties, such as nontoxicity, satisfactory photothermal conversion efficacy, etc. However, the biomedical applications of Ti NSs have not been intensively investigated. Herein, we synthesized a multifunctional Ti NS drug delivery system modified with polydopamine/polyethylene glycol (Ti@PDA-PEG) and applied simultaneously for photothermal therapy and chemotherapy. Doxorubicin (DOX) was utilized as a model drug. Ti@PDA-PEG NS shows an ultrahigh antitumor drug DOX loading (Ti@PDA-PEG-DOX). The prepared Ti@PDA-PEG-DOX NS as robust drug delivery system demonstrates great stability and excellent multi-response drug-release capabilities, including pH-responsive and near-infrared -responsive behavior and obviously high photothermal efficiency. Both in vitro and in vivo experimental results have shown high biosafety and outstanding antitumor effects. Therefore, this work exhibits the enormous potential of a multifunctional platform in the treatment of tumors and may stimulate interest in the exploration of other new 2D nanomaterials for biomedical applications.

• Authors: Xiaoli Yuan, Ying Zhu, Shasha Li, Yiqun Wu, Zhongshi Wang, Rui Gao, Shiyao Luo, Juan Shen, Jun Wu, Liang Ge
• Journal: Journal of nanobiotechnology (J Nanobiotechnology) Vol. 20 Issue 1 Pg. 154 (Mar 24 2022) ISSN: 1477-3155 [Electronic] England
• PMID: 35331256 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Drug Carriers
• Titanium

Topics

• Containment of Biohazards
• Drug Carriers (therapeutic use)
• Humans
• Nanoparticles (therapeutic use)
• Neoplasms (drug therapy, pathology)
• Phototherapy (methods)
• Titanium