Abstract | OBJECTIVE:
Eccrine porocarcinoma ( EPC) is a malignant adnexal tumor accounting for about 0.005% of skin tumors. The standard treatment of EPC is the complete surgical excision of the primary lesion and of the clinically involved lymph nodes. There is limited evidence regarding the role of radiotherapy (RT) in managing EPC after surgery. Therefore, the aim of this multidisciplinary systematic review is to analyze the available evidence about postoperative RT in the curative treatment of EPC. MATERIALS AND METHODS: RESULTS: A total of 104 publications were identified and 14 papers were included in the final analysis. The only articles found on adjuvant RT in EPC were case reports published between 1996 and 2019. There was a slight female prevalence (57% female/43% male) with a mean age of 65 years (range 37-85). Head-and-neck region was the most frequently involved anatomical site followed by legs. CONCLUSIONS:
Adjuvant radiotherapy after surgical removal of EPC could be considered in cases with positive or close margins and in cases with unfavorable histological features. In view of limited literature data and the rarity of EPC the best treatment sequence should always be discussed within the frame of a multidisciplinary setting. ADVANCES IN KNOWLEDGE:
adjuvant radiotherapy after surgical removal of EPC could be considered in cases with positive or close margins and in cases with unfavorable histological features.
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Authors | B Fionda, A Di Stefani, V Lancellotta, S Gentileschi, A A Caretto, C Casà, F Federico, A Rembielak, E Rossi, A G Morganti, G Schinzari, K Peris, L Tagliaferri |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 26
Issue 5
Pg. 1695-1700
(Mar 2022)
ISSN: 2284-0729 [Electronic] Italy |
PMID | 35302218
(Publication Type: Journal Article, Systematic Review)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Eccrine Porocarcinoma
(pathology, radiotherapy, surgery)
- Female
- Humans
- Male
- Middle Aged
- Radiotherapy, Adjuvant
- Sweat Gland Neoplasms
(pathology, radiotherapy, surgery)
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