Abstract | BACKGROUND: Recently, triglyceride deposit cardiomyovasculopathy (TGCV) with defective intracellular lipolysis was found to be a disease that causes heart failure. As a diagnostic criterion for TGCV, an Iodaine-123-β-methyl iodophenyl- pentadecanoic acid washout rate ( BMIPP WOR) of < 10% is used, but its clinical significance in patients with heart failure remains to be clarified. METHODS: In 62 hospitalized patients with chronic heart failure, 123I-BMIPP myocardial single-photon emission computed tomography (SPECT) was performed predischarge state. The prevalence of TGCV was investigated. Subsequently, follow-up was conducted for ≥ 90 days (mean: 724.6 ± 392.7 days), and the association between the BMIPP WOR and cardiac events was examined, establishing all-cause mortality and admission due to heart failure as endpoints. RESULTS: Of the 62 patients, the WOR was < 10% in 41 (66.1%). Of these, 26 (41.9%) were diagnosed with definite TGCV. Furthermore, cardiac events were noted in 12 patients (19.4%). Analysis with Cox proportional hazards models showed that the BMIPP WOR < 4.5% was a significant event-predicting factor [HR 4.29, 95% CI: 1.20-16.87; p = 0.0245]. On a Kaplan-Meier curve, the WOR was 4.5%; there was a significant difference in the incidence of events (p = 0.0298). CONCLUSION: In the predischarge state of heart failure, 123I-BMIPP myocardial SPECT was performed. In approximately 40% of the patients, a diagnosis of TGCV was made. The results suggested that the BMIPP WOR is useful for predicting the prognosis of chronic heart failure patients regardless of TGCV.
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Authors | Chihiro Aoshima, Shinichiro Fujimoto, Ayako Kudo, Yuko O Kawaguchi, Kazuhisa Takamura, Yuya Matsue, Takao Kato, Yoshifumi Kawamura, Satoshi Kimura, Yuki Kamo, Yui O Nozaki, Daigo Takahashi, Nobuo Tomizawa, Makoto Hiki, Takatoshi Kasai, Shuko Nojiri, Hideyuki Miyauchi, Ken-Ichi Hirano, Kazunori Shimada, Koji Murakami, Tohru Minamino |
Journal | European journal of nuclear medicine and molecular imaging
(Eur J Nucl Med Mol Imaging)
Vol. 49
Issue 9
Pg. 3129-3139
(07 2022)
ISSN: 1619-7089 [Electronic] Germany |
PMID | 35298692
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Chemical References |
- Fatty Acids
- Iodine Radioisotopes
- Iodobenzenes
- iodofiltic acid
- Iodine-123
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Topics |
- Chronic Disease
- Fatty Acids
- Heart
- Heart Failure
(diagnostic imaging)
- Humans
- Iodine Radioisotopes
- Iodobenzenes
- Tomography, Emission-Computed, Single-Photon
(methods)
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