Colistin sulfate for decontamination of preservation fluid in kidney transplantation to decrease the incidence of donor-derived infections caused by multidrug-resistant Gram-negative bacteria.

Abstract

BACKGROUND:

Preservation fluid (PF) contamination, especially by multidrug-resistant (MDR) Gram-negative bacteria (GNB), poses a high risk of donor-derived infection (DDI) and severe clinical outcomes. We sought to determine whether the use of colistin sulfate to decontaminate PF in kidney transplantation can decrease the incidence of probable DDI (p-DDI) caused by MDR GNB.

METHODS:

In a retrospective study of 916 recipients who received deceased donation, 864 PF samples were collected and cultured, and microbiological contaminants were recorded with the recipients' clinical data and outcomes. From March 2016 to May 2019, 624 samples were decontaminated with ceftizoxime, and from June 2019 to March 2021, 240 samples were decontaminated with colistin sulfate. Between-group comparisons were performed to assess the ability of the two decontamination regimens to decrease the incidence of p-DDI, especially MDR GNB-related infection.

RESULTS:

The overall PF contamination rate was 54.51% (471/864), and 80 samples were positive for MDR GNB contamination. All p-DDIs occurred in the ceftizoxime group (p < 0.001), and 67.65% of p-DDIs were MDR GNB-related. In the ceftizoxime group, 23 of 61 cases of MDR GNB contamination led to related p-DDIs, while none occurred in the colistin sulfate group (p = 0.002). Among the 23 patients with p-DDIs, 5 died due to severe infection, and 2 experienced graft loss.

CONCLUSIONS:

The goal of decontamination should be to decrease the risk of MDR GNB-related p-DDI, and colistin sulfate could be an effective and feasible option.

• Authors: Mingxing Sui, Nanxin Zheng, Da Xu, Yuhong Li, Yanhua Li, Shijun Pu, Meili Ji, Suxia Yang, Yutong Chen, Juan Huang, Youhua Zhu, Hanlan Lu, Li Zeng
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 24 Issue 3 Pg. e13820 (Jun 2022) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 35279926 (Publication Type: Journal Article)
• Copyright: © 2022 Wiley Periodicals LLC.

Chemical References

• Anti-Bacterial Agents
• Ceftizoxime
• Colistin

Topics

• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Ceftizoxime (pharmacology)
• Colistin (therapeutic use)
• Decontamination
• Drug Resistance, Multiple, Bacterial
• Gram-Negative Bacteria
• Gram-Negative Bacterial Infections (drug therapy, epidemiology, prevention & control)
• Humans
• Incidence
• Kidney Transplantation (adverse effects)
• Retrospective Studies