Prognostic significance of wait time for radical radiotherapy in locoregionally advanced nasopharyngeal carcinoma.

Abstract

BACKGROUND:

The prognostic significance of wait time between definite diagnosis and initial radical radiotherapy is not well established in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) receiving both induction chemotherapy (IC) and concurrent chemoradiotherapy (CCRT).

METHODS:

From 2010 to 2018, 648 patients with LA-NPC treated with IC followed by CCRT were included.

RESULTS:

A total of 172 pairs of patients with LA-NPC were selected by propensity score matching (PSM). Compared to patients with an acceptable wait time (≤75 days), patients with a prolonged wait time (>75 days) had a significant lower 5-year DMFS rate (86.6% vs. 74.1%, p = 0.006). Subgroup analyses indicated that the unfavorable effects of longer waiting times were mainly seen among stage IVa patients.

CONCLUSIONS:

A prolonged wait time (>75 days) between definite diagnosis and initial radical radiotherapy has negative prognostic effects on patients with LA-NPC receiving IC plus CCRT, particularly those with IVa stage.

• Authors: Yu-Ting Jiang, Kai-Hua Chen, Jie Yang, Zhong-Guo Liang, Song Qu, Ling Li, Xiao-Dong Zhu
• Journal: Head & neck (Head Neck) Vol. 44 Issue 5 Pg. 1182-1191 (05 2022) ISSN: 1097-0347 [Electronic] United States
• PMID: 35218120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 Wiley Periodicals LLC.

Chemical References

• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemoradiotherapy (adverse effects)
• Cisplatin
• Humans
• Induction Chemotherapy
• Nasopharyngeal Carcinoma (drug therapy, radiotherapy)
• Nasopharyngeal Neoplasms (drug therapy, radiotherapy)
• Prognosis
• Waiting Lists