Population-genetic Aspects of Breast Cancers and Association with Rh Factor in Selected Sample.

Abstract

BACKGROUND:

Breast cancer in women is the second most common and accounts for approximately 18% of all malignant tumors in women worldwide. The etiology of breast cancer is not clear enough. Starting from the assumption that the manifestation of breast cancer may have a multifactorial model, this article compares the population-genetic structure of patients (experimental group) with the population-genetic structure of healthy population (control group).

OBJECTIVE:

The aim of the study was to examine the possible genetic basis of the Rh factor relationship with selected homozygous-recessive traits of females with breast cancer, and to diagnose the probability (assess the risk) of developing the disease in healthy women by analyzing homozygous-recessive traits (HRT).

METHODS:

This are an anthroposcopic-qualitative study that included two groups of subjects, experimental and control (a total of 80 subjects). An analysis of the percentages within each group was performed using the Chi-square test. The results are presented in tables, and the accepted level of significance is at the level of p <0.05.

RESULTS:

In the group of Rh+ subjects, the correlation of this type of Rh factor with the breast cancer was proven, given the frequency of the phenotype of homozygous-recessive traits in them. A statistically significant difference was found for 4 traits, and three are also close to the set significance level. In subjects with Rh- factor, a statistically significant difference was found for only one trait (absence of mallets on the phalanges).

CONCLUSION:

Although the number of subjects was relatively small, we can conclude that in the experimental group a higher frequency of recessive phenotypes for the examined traits was recorded, which indicates the genetic load of the subjects from this group. Correlation with Rh factor was observed in the case of subjects of the experimental group with Rh+ factor.

• Authors: Azra Metovic, Jasmin Musanovic, Nerman Ramic, Orhan Lepara, Damir Secic, Esad Pepic, Svjetlana Loga Zec, Senad Sljuka
• Journal: Medical archives (Sarajevo, Bosnia and Herzegovina) (Med Arch) Vol. 75 Issue 6 Pg. 413-417 (Dec 2021) ISSN: 1986-5961 [Electronic] Bosnia and Herzegovina
• PMID: 35169367 (Publication Type: Journal Article)
• Copyright: © 2021 Azra Metovic, Jasmin Musanovic, Nerman Ramic, Orhan Lepara, Damir Secic, Esad Pepic, Svjetlana Loga Zec, Senad Sljuka.

Chemical References

• Rh-Hr Blood-Group System

Topics

• Breast Neoplasms (epidemiology, genetics)
• Case-Control Studies
• Female
• Humans
• Rh-Hr Blood-Group System