Abstract | OBJECTIVES: The aim of this retrospective study was to assess outcomes of SABR for metachronous isolated lung oligometastases from HNSCC. METHODS: For patients who developed isolated, 1 or 2 lungs lesions (<5cm) consistent with metastases from HNSCC, the indication of SABR was validated in a multidisciplinary tumor board. All patients were monitored by CT or PET CT after SABR (Stereotactic Ablative Body Radiation) for HNSCC. RESULTS: Between November 2007 and February 2018, 52 patients were treated with SABR for metachronous lung metastases. The median time from the treatment of the primary HNSCC to the development of lung metastases was 18 months (3-93). The cohort's median age was 65.5 years old (50-83). The vast majority (94.2%) received 60 Gy in three fractions. Forty-one patients (78.5%) presented a solitary lung metastasis, while 11 patients (21.5%) had two lung metastases. With a median follow-up of 45.3 months, crude local and metastatic control rates were 74 and 38%, respectively. 1 year and 2 year Overall Survival (OS) were 85.8 and 65.9%, respectively. The median OS was 46.8 months. About one-fourth of patients were retreated by SABR for distant pulmonary recurrence. The treatment was well tolerated with only one patient who reported ≥ grade 3 toxicity (1.9%). CONCLUSION: In selected metastatic HNSCC patients, early detection and treatment of lung metastases with SABR is effective and safe. Prospective studies are required to validate this potential shift. ADVANCES IN KNOWLEDGE:
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Authors | Kamel Debbi, Gokoulakrichenane Loganadane, Nhu Hanh To, Remy Kinj, Zain A Husain, Sophie Chapet, Nam P Nguyen, Isabelle Barillot, Karen Benezery, Yazid Belkacemi, Gilles Calais |
Journal | The British journal of radiology
(Br J Radiol)
Vol. 95
Issue 1133
Pg. 20210033
(May 01 2022)
ISSN: 1748-880X [Electronic] England |
PMID | 35143326
(Publication Type: Journal Article)
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Topics |
- Aged
- Head and Neck Neoplasms
(radiotherapy)
- Humans
- Lung
(pathology)
- Lung Neoplasms
(diagnostic imaging, radiotherapy)
- Radiosurgery
- Retrospective Studies
- Squamous Cell Carcinoma of Head and Neck
- Treatment Outcome
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