PREDICTORS OF RETINAL PIGMENT EPITHELIUM TEAR DEVELOPMENT AFTER TREATMENT FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Abstract

PURPOSE:

The purpose of this study was to investigate the predictors of retinal pigment epithelium (RPE) tear development after treatment for neovascular age-related macular degeneration using swept source optical coherence tomography angiography.

METHODS:

This prospective study included 152 treatment-naïve eyes with neovascular age-related macular degeneration without high myopia that were followed up for 1 year after treatment. Eligible eyes were classified into eyes with or without RPE tear development. They were matched in a 1:2 ratio. The areas of choroidal neovascularization (CNV) and RPE detachment (pigment epithelial detachment [PED]) were measured from optical coherence tomography angiography and OCT en face images, respectively. The optical coherence tomography angiography-specific parameters representing CNV status were analyzed.

RESULTS:

Eight (5.3%) of the 152 eyes developed RPE tears (RPE tear group). After matching, 16 eyes without RPE tears were analyzed (non-RPE tear group). The ratio of the CNV/PED area was lower in the RPE tear group than that in the non-RPE tear group (P = 0.007). The PED area was broader (P = 0.008), and PED height was greater in the RPE tear group (P = 0.04). Optical coherence tomography angiography-specific parameters did not differ between the two groups.

CONCLUSION:

Neovascular age-related macular degeneration with pretreatment broad PED, high PED, and small CNV area relative to the PED area has a high risk of RPE tear development after therapy. However, CNV status may not have an association.

• Authors: Satoshi Yasuhara, Manabu Miyata, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda-Arakawa, Akihito Uji, Yuki Muraoka, Masahiro Miyake, Ayako Takahashi, Tomotaka Wakazono, Kenji Yamashiro, Akitaka Tsujikawa
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 42 Issue 6 Pg. 1020-1027 (06 01 2022) ISSN: 1539-2864 [Electronic] United States
• PMID: 35125477 (Publication Type: Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Vascular Endothelial Growth Factor A

Topics

• Angiogenesis Inhibitors (therapeutic use)
• Choroidal Neovascularization (diagnosis, drug therapy)
• Fluorescein Angiography
• Humans
• Macular Degeneration (drug therapy)
• Prospective Studies
• Retinal Detachment (diagnosis, drug therapy, etiology)
• Retinal Pigment Epithelium (blood supply)
• Retrospective Studies
• Tomography, Optical Coherence
• Vascular Endothelial Growth Factor A