Impact of HPV status on metastatic patterns and survival in non-oropharyngeal head and neck cancer with distant metastasis.

Abstract

PURPOSE:

Because of the lack of data and studies on metastatic non-oropharyngeal head and neck cancer (non-OP HNC), the role of human papillomavirus (HPV) status in non-OP HNC with distant metastasis is still unclear. Therefore, we conducted a study to explore the differences in metastatic patterns, survival and treatment responses in metastatic non-OP HNC based on HPV status.

METHODS:

A total of 333 metastatic non-OP HNC patients were diagnosed from 2010 to 2016 in the Surveillance, Epidemiology and End Results (SEER) database. The chi-square test and Fisher's exact test were used to make comparisons for categorical variables. The Kaplan-Meier method and Cox regression analyses were used to analyse survival.

RESULTS:

HPV status was a significant prognostic variable for patients with non-OP HNC with distant metastasis. HPV- patients were more likely to have distant metastasis and worse prognosis and treatment response than HPV+ patients. Only chemotherapy was an independent prognostic factor for HPV+ patients with distant metastasis, while chemotherapy and radiotherapy were both independent prognostic factors for HPV- patients with distant metastasis. The treatment response was associated with the metastatic pattern in both HPV+ and HPV- populations and showed significant differences based on HPV status and metastatic pattern.

CONCLUSIONS:

For non-OP HNC with distant metastasis, HPV+ and HPV- patients formed two different cohorts in terms of metastatic pattern, survival and treatment. Therefore, it is helpful to classify metastatic non-OP HNC into different groups to choose appropriate treatment strategies according to HPV status and metastatic pattern.

• Authors: Ping Wang, Shuang Zang, Miao Zhang, Guang Li, Yan Wang, Qiao Qiao
• Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 279 Issue 6 Pg. 3029-3039 (Jun 2022) ISSN: 1434-4726 [Electronic] Germany
• PMID: 35124745 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Topics

• Alphapapillomavirus
• Head and Neck Neoplasms (complications, therapy)
• Humans
• Oropharyngeal Neoplasms (pathology)
• Papillomaviridae
• Papillomavirus Infections (epidemiology)
• Prognosis
• Retrospective Studies