Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population.

Abstract

Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24-50 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS ≥ 1 risk allele than those with a metabolic-GRS < 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (Pinteraction = 0.040). Participants carrying a metabolic-GRS ≥ 1 risk allele and consuming a high fat diet (≥38% of energy = 122.3 ± 52.51 g/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (<38% of energy = 82.5 ± 37.36 g/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (<35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status.

• Authors: Kubra Isgin-Atici, Buthaina E Alathari, Busra Turan-Demirci, Suleyman Nahit Sendur, Incilay Lay, Basma Ellahi, Mehmet Alikasifoglu, Tomris Erbas, Zehra Buyuktuncer, Karani Santhanakrishnan Vimaleswaran
• Journal: Nutrients (Nutrients) Vol. 14 Issue 2 (Jan 17 2022) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 35057563 (Publication Type: Journal Article)

Chemical References

• Dietary Fats
• Lipids
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Adult
• Body Mass Index
• Cross-Sectional Studies
• Dietary Fats (administration & dosage)
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Lipids (blood)
• Metabolic Diseases (genetics)
• Middle Aged
• Nutrigenomics
• Polymorphism, Single Nucleotide (genetics)
• Risk Factors
• Turkey (epidemiology)
• Vitamin D (analogs & derivatives, blood)
• Vitamin D Deficiency (epidemiology)