With the development of proteomics and epigenetics, a large number of
RNA-binding proteins (RBPs) have been discovered in recent years, and the interaction between long non-coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in-depth research on the
lncRNA-RBP interaction network, especially in the context of its role in the occurrence and development of
cancer. Increasing evidence has demonstrated that
lncRNA-RBP interactions play a vital role in
cancer progression; therefore, targeting these interactions could provide new insights for
cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to
cancer development, such as
N6-methyladenosine (m6A) modification of lncRNAs. In addition, we discussed how the
lncRNA-RBP interaction network regulates
cancer cell phenotypes, such as proliferation, apoptosis,
metastasis, drug resistance, immunity,
tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the
lncRNA-RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for
cancer treatment.