TTRE, a
photosensitizer molecule, has excellent biofluorescence imaging performance and effective antitumor properties for
breast cancer. However, its application in
breast cancer treatment is limited due to poor
tumor selectivity and lack of targeting ability. In this study, TTRE and
trastuzumab were combined to synthesize Tra-TTR-A, a novel near-infrared fluorescent nanoprobe for HER2 positive
breast cancer. The targeting and antitumor abilities of Tra-TTR-A in
breast cancer were also investigated. Like TTRE, Tra-TTR-A has a stable structure with remarkable optical properties and in vivo imaging capacity. However, Tra-TTR-A not only inhibits
tumor growth by generating
reactive oxygen species but also kills
tumor cells by
trastuzumab. In this study, Tra-TTR-A, a new type of near-infrared fluorescent nanoprobe that targets HER2-positive
breast cancer, was successfully synthesized. Tra-TTR-A could be used in in vivo imaging, targeted
photodynamic therapy, and diagnosis and treatment for
breast cancer.