Injectable glycol chitosan thermogel formulation for efficient inner ear drug delivery.

Abstract

We prepared a new injectable thermogel to enhance the efficiency of inner ear delivery of dexamethasone (DEX). Hexanoyl glycol chitosan (HGC) was synthesized and evaluated as an amphiphilic thermogel (Tgel ~ 32 °C) for use as a solubilizing agent as well as an injectable carrier for intratympanic delivery of the hydrophilic and hydrophobic forms of DEX. Various thermogel formulations with different drug types and concentrations were prepared, and their physicochemical and thermogelling properties were characterized by 1H NMR, ATR-FTIR, and rheometer. They exhibited versatile release kinetics from several hours to more than 2 weeks, depending on drug type and concentration. Our formulations further showed good residual stability for more than 21 days without any cytotoxicity or inflammation in the middle and inner ear and could deliver a considerably high drug concentration into the inner ear. Therefore, HGC thermogel has great potential as an effective and safe formulation for inner ear drug delivery.

• Authors: Yang Yu, Da Hae Kim, Eun Yeong Suh, Seong-Hun Jeong, Hyuk Chan Kwon, Thi Phuc Le, Yugyeong Kim, Sun-Ae Shin, Yong-Ho Park, Kang Moo Huh
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 278 Pg. 118969 (Feb 15 2022) ISSN: 1879-1344 [Electronic] England
• PMID: 34973784 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Drug Carriers
• Gels
• glycol-chitosan
• Dexamethasone
• Chitosan

Topics

• Animals
• Chitosan (administration & dosage, chemical synthesis, chemistry)
• Dexamethasone (administration & dosage, chemistry, pharmacology)
• Drug Carriers (administration & dosage, chemical synthesis, chemistry)
• Drug Compounding
• Drug Delivery Systems
• Ear, Inner (drug effects)
• Gels (administration & dosage, chemical synthesis, chemistry)
• Guinea Pigs
• Male
• Molecular Structure
• Temperature