Novel design of bandages using cotton pads, doped with chitosan, glycogen and ZnO nanoparticles, having enhanced antimicrobial and wounds healing effects.

Abstract

In this present work, a new design for antimicrobial wound bandages is presented. The wound dressings were prepared using cotton fibers reinforced with elastic compression straps and secured with a polyester fabric of tight mesh size. The cotton pads were doped with a wound healing biocomposite, composed of chitosan, glycogen, and ZnO nanoparticles (CG@ZnONPs) previously formulated through a green process. The size of ZnONPs in the prepared CG@ZnONPs was 30-80 nm. The cotton pads impregnated with the CG@ZnONPs nanocomposite were characterized using FTIR, SEM, EDX, TGA, and DTGA methods. Moreover, the prepared dressings were tested on a number of intentionally injured rats. In this experiment, the % contraction of the treated wounds was monitored and compared to that of a control group of wounded rats, to which only sterile gauzes were applied. The results showed a much faster and an almost complete healing of rats treated with the synthesized dressings and the results were further confirmed by histopathological examination. The dressings were also found to exert a significant antimicrobial activity against a number of pathogenic microorganisms, generally encountered in common wounds, and could therefore be recommended to be a novel biomedical application for a fast, successful, and flawless wounds healing process.

• Authors: Mohamed Hasanin, Eman M Swielam, Nagwa A Atwa, Mona M Agwa
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 197 Pg. 121-130 (Feb 01 2022) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 34963623 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Chitosan

Topics

• Chitosan