Tumor-derived biomimetic nanozyme with immune evasion ability for synergistically enhanced low dose radiotherapy.

Abstract

High doses of radiation can cause serious side effects and efficient radiosensitizers are urgently needed. To overcome this problem, we developed a biomimetic nanozyme system (CF) by coating pyrite (FeS2) into tumor-derived exosomes for enhanced low-dose radiotherapy (RT). CF system give FeS2 with immune escape and homologous targeting abilities. After administration, CF with both glutathione oxidase (GSH-OXD) and peroxidase (POD) activities can significantly lower the content of GSH in tumor tissues and catalyze intracellular hydrogen peroxide (H2O2) to produce a large amount of ·OH for intracellular redox homeostasis disruption and mitochondria destruction, thus reducing RT resistance. Experiments in vivo and in vitro showed that combining CF with RT (2 Gy) can provide a substantial suppression of tumor proliferation. This is the first attempt to use exosomes bionic FeS2 nanozyme for realizing low-dose RT, which broaden the prospects of nanozymes.

• Authors: Chunyu Huang, Zeming Liu, Mingzhu Chen, Liang Du, Chunping Liu, Shuntao Wang, Yongfa Zheng, Wei Liu
• Journal: Journal of nanobiotechnology (J Nanobiotechnology) Vol. 19 Issue 1 Pg. 457 (Dec 28 2021) ISSN: 1477-3155 [Electronic] England
• PMID: 34963466 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s).

Chemical References

• Enzymes
• Radiation-Sensitizing Agents
• Sulfides
• pyrite
• Hydrogen Peroxide
• Iron
• Glutathione

Topics

• Animals
• Biomimetic Materials (administration & dosage, chemistry, metabolism, pharmacology)
• Cell Line, Tumor
• Enzymes (administration & dosage, chemistry, metabolism)
• Exosomes (chemistry, immunology)
• Glutathione (metabolism)
• Hydrogen Peroxide (metabolism)
• Immune Evasion
• Iron (administration & dosage, chemistry)
• Mice
• Mitochondria (drug effects)
• Nanostructures (administration & dosage, chemistry)
• Neoplasms (metabolism, radiotherapy)
• Oxidation-Reduction (drug effects)
• Radiation-Sensitizing Agents (administration & dosage, chemistry, metabolism, pharmacology)
• Radiotherapy Dosage
• Sulfides (administration & dosage, chemistry)