[Cerebrospinal fluid distribution of metampicillin (author's transl)].

Abstract

UNLABELLED:

In order to avoid other antibiotics which interfere with plasma and CSF level determination of a given antibiotic the authors use a chemical method of established specificity. 15 patients presenting with purulent meningitis were given a standard daily dose of metampicillin and divided into 3 groups of 5. On days 2, 4 and 6 after onset of disease plasma and CSF specimens were taken at respectively 1, 2 or 4 hours following metampicillin I.V. injection according to patient group. All patients were cured between days 7 and 21 of therapy. Tolerance was good.

RESULTS:

--there was no correlation between dose injected and plasma level of drug,--CSF distribution of metampicillin was good and stayed identical throughout the disease period,--peak CSF drug level was delayed as compared to plasma level, occurring more than 4 hours after I.V. injection of metampicillin.

• Authors: J B Dureux, P Canton, J L Pecqueux, F Belleville, M F Biava, G Chanteclair
• Journal: Pathologie-biologie (Pathol Biol (Paris)) Vol. 25 Issue 10 Pg. 699-703 (Dec 1977) ISSN: 0369-8114 [Print] France
• Vernacular Title: Cinétique intra-rachidienne de la métampicilline.
• PMID: 349485 (Publication Type: Journal Article)

Chemical References

• Ampicillin
• methampicillin

Topics

• Ampicillin (administration & dosage, analogs & derivatives, blood, cerebrospinal fluid)
• Blood-Brain Barrier
• Humans
• Injections, Intravenous
• Kinetics
• Meningitis (drug therapy)
• Methods
• Time Factors