Pure and Mixed Tubular Carcinoma of the Breast: Mammographic Features, Clinicopathological Characteristics and Prognostic Analysis.

Abstract

Objective: To evaluate the mammographic features, clinicopathological characteristics, treatments, and prognosis of pure and mixed tubular carcinomas of the breast. Materials and methods: Twenty-five tubular carcinomas were pathologically confirmed at our hospital from January 2011 to May 2019. Twenty-one patients underwent preoperative mammography. A retrospective analysis of mammographic features, clinicopathological characteristics, treatment, and outcomes was performed. Results: Altogether, 95% of the pure tubular carcinomas (PTCs) and mixed tubular carcinomas (MTCs) showed the presence of a mass or structural distortions on mammography and the difference was not statistically significant (P = .373). MTCs exhibited a larger tumor size than PTCs (P = .033). Lymph node metastasis was more common (P = .005) in MTCs. Patients in our study showed high estrogen receptor and progesterone receptor positivity rates, but low human epidermal growth factor receptor 2 positivity rate. The overall survival rate was 100% in both PTC and MTC groups and the 5-year disease-free survival rates were 100% and 75%, respectively with no significant difference between the groups (P = .264). Conclusion: Tubular carcinoma of the breast is potentially malignant and has a favorable prognosis. Digital breast tomosynthesis may improve its detection. For patients with PTC, breast-conserving surgery and sentinel lymph node biopsy are recommended based on the low rate of lymph node metastasis and good prognosis. MTC has a relatively high rate of lymph node metastasis and a particular risk of metastasis. Axillary lymph node dissection should be performed for MTC even if the tumor is smaller than 2 cm.

• Authors: Chanjuan Wen, Weimin Xu, Genggeng Qin, Hui Zeng, Zilong He, Sina Wang, Zeyuan Xu, Mengwei Ma, Zhendong Luo, Weiguo Chen
• Journal: Technology in cancer research & treatment (Technol Cancer Res Treat) 2021 Jan-Dec Vol. 20 Pg. 15330338211045198 ISSN: 1533-0338 [Electronic] United States
• PMID: 34918991 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Estrogen
• Receptors, Progesterone

Topics

• Adenocarcinoma (diagnostic imaging, pathology, surgery)
• Adult
• Aged
• Aged, 80 and over
• Breast Neoplasms (diagnostic imaging, pathology, surgery)
• Disease-Free Survival
• Female
• Humans
• Lymph Node Excision
• Lymph Nodes (pathology, surgery)
• Lymphatic Metastasis
• Mammography (methods)
• Mastectomy, Segmental
• Middle Aged
• Neoplasm Recurrence, Local (pathology)
• Neoplasms, Complex and Mixed (diagnostic imaging, pathology, surgery)
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• Retrospective Studies
• Sentinel Lymph Node Biopsy
• Survival Rate
• Tumor Burden