Red-emitting fluorogenic BODIPY-tetrazine probes for biological imaging.

Abstract

A series of new BODIPY-tetrazine derivatives have been developed with a twist intramolecular charge transfer (TICT) state in polar solvents, which is an electron transfer process that occurs upon photoexcitation in a molecule that usually consists of an electron donor and acceptor linked by a single bond. Among them, the BODIPY-tetrazine derivative 6i was stable towards long-term storage and red-emitting with excellent performance, and was further used to image trans-cyclooctene-labeled lipids in mammalian cells and cyclopropene-labeled sugars in cancer cells under no-wash conditions.

• Authors: Lei Chen, Fei Li, Yan Li, Jun Yang, Yongjun Li, Bin He
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 58 Issue 2 Pg. 298-301 (Dec 23 2021) ISSN: 1364-548X [Electronic] England
• PMID: 34889325 (Publication Type: Journal Article)

Chemical References

• 1,2,4,5-tetrazine
• 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
• Aza Compounds
• Benzene Derivatives
• Boron Compounds
• Fluorescent Dyes

Topics

• A549 Cells
• Aza Compounds (chemistry)
• Benzene Derivatives (chemistry)
• Boron Compounds (chemistry)
• Fluorescent Dyes (chemistry)
• Humans
• Molecular Structure
• Optical Imaging