HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review.

Abstract
Despite numerous promising therapeutic targets, there are no proven medical treatments for calcific aortic stenosis (AS). Multiple stakeholders need to come together and several scientific, operational, and trial design challenges must be addressed to capitalize on the recent and emerging mechanistic insights into this prevalent heart valve disease. This review briefly discusses the pathobiology and most promising pharmacologic targets, screening, diagnosis and progression of AS, identification of subgroups that should be targeted in clinical trials, and the need to elicit the patient voice earlier rather than later in clinical trial design and implementation. Potential trial end points and tools for assessment and approaches to implementation and design of clinical trials are reviewed. The efficiencies and advantages offered by a clinical trial network and platform trial approach are highlighted. The objective is to provide practical guidance that will facilitate a series of trials to identify effective medical therapies for AS resulting in expansion of therapeutic options to complement mechanical solutions for late-stage disease.
AuthorsBrian R Lindman, Devraj Sukul, Marc R Dweck, Mahesh V Madhavan, Benoit J Arsenault, Megan Coylewright, W David Merryman, David E Newby, John Lewis, Frank E Harrell Jr, Michael J Mack, Martin B Leon, Catherine M Otto, Philippe Pibarot
JournalJournal of the American College of Cardiology (J Am Coll Cardiol) Vol. 78 Issue 23 Pg. 2354-2376 (12 07 2021) ISSN: 1558-3597 [Electronic] United States
PMID34857095 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
CopyrightCopyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Hypolipidemic Agents
Topics
  • Aortic Valve (pathology)
  • Aortic Valve Stenosis (complications, drug therapy, etiology)
  • Calcinosis (complications, drug therapy)
  • Disease Progression
  • Humans
  • Hypolipidemic Agents (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: