Visual and histological evaluation of the effects of trafermin in a dog oronasal fistula model.

Abstract

The standard procedure to treat oronasal fistula in dogs requires tooth extraction to close the fistula; hence, the subject would lose its tooth. In this study, trafermin was applied to four dog models with oronasal fistula to investigate the periodontal tissue regenerative effects of trafermin in the treatment without tooth extraction. A fistula was created along the palatal side of each upper canine tooth. One of the fistulae was filled with trafermin, whereas that on the contralateral side was left unfilled as a control. The results showed a significant decrease in the non-calcified periodontal tissue volume on the trafermin side after the fourth week. In addition, oronasal fistula closure was visually and histologically confirmed at the eighth week on the trafermin side of all four models.

• Authors: Kazuhiro Watanabe, Syun Tahara, Hiroyuki Koyama, Mamu Shimizu, Mifumi Kawabe, Shingo Miyawaki
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 84 Issue 1 Pg. 64-68 (Jan 07 2022) ISSN: 1347-7439 [Electronic] Japan
• PMID: 34803085 (Publication Type: Journal Article)

Chemical References

• Peptide Fragments
• trafermin
• Fibroblast Growth Factors

Topics

• Animals
• Dog Diseases
• Dogs
• Fibroblast Growth Factors
• Fistula (veterinary)
• Nose Diseases (veterinary)
• Oral Fistula (veterinary)
• Peptide Fragments