Abstract | BACKGROUND: Head and neck mucosal melanoma is a rare malignant disease with no clear and effective treatment to control the prognosis of patients. AIM: To analyze the effects of different postoperative adjuvant treatments on the survival and prognosis of patients. MATERIAL AND METHODS: A retrospective analysis of 163 patients which were divided into five groups: no adjuvant therapy, postoperative radiotherapy, postoperative chemotherapy, postoperative chemotherapy and radiotherapy, and postoperative immunotherapy. Kaplan-Meier method and Cox regression analysis were used to analyze the prognosis in the different groups. RESULTS: CONCLUSIONS AND SIGNIFICANCE: For the head and neck mucosal melanoma, different types adjuvant therapy can prolong the survival of patients to varying degrees compared with no postoperative treatment, but immunotherapy as a single adjuvant therapy does not show any advantages. We recommended that patients should receive radiotherapy and/or chemotherapy after surgery.
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Authors | Gaofei Yin, Wei Guo, Zhigang Huang, Xiaohong Chen |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 141
Issue 11
Pg. 1014-1021
(Nov 2021)
ISSN: 1651-2251 [Electronic] England |
PMID | 34766867
(Publication Type: Journal Article)
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Topics |
- Aged
- Chemotherapy, Adjuvant
- China
- Female
- Head and Neck Neoplasms
(mortality, surgery, therapy)
- Humans
- Immunotherapy
- Kaplan-Meier Estimate
- Male
- Melanoma
(mortality, surgery, therapy)
- Middle Aged
- Prognosis
- Proportional Hazards Models
- Radiotherapy, Adjuvant
- Retrospective Studies
- Survival Rate
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