Surgical and survival outcomes after laparoscopic and open gastrectomy for serosa-invasive Siewert type II/III esophagogastric junction carcinoma: a propensity score matching analysis.

Abstract

BACKGROUND:

The potential advantage of laparoscopic gastrectomy (LG) compared with open gastrectomy (OG) for serosa-invasive (pT4a) Siewert type II and III adenocarcinoma of the esophagogastric junction (AEG) remains uncertain. Thus, the purpose of this study was to investigate the short- and long-term outcomes of LG compared to OG for pT4a Siewert type II/III AEG cancers.

METHODS:

We retrospectively evaluated 283 patients with pathological confirmed T4a Siewert type II and type III AEG who underwent LG or OG in our center between January 2004 and September 2015. The short- and long-term outcomes were compared between the groups using a 1:1 matched propensity score matching method (PSM).

RESULTS:

The LG group had a longer operation time, less estimated blood loss, less time to first flatus, less time to start liquid diet, less time to first ambulation, and shorter length of incision than the OG group. The conversion rates were 5.4% in the LG groups. There was no significant difference in the overall complication rate between the LG and OG groups. The 5-year overall survival (OS) and the 5-year disease-free survival (DFS) were comparable between the LG and OG groups (35.4% vs 32.1%, p = 0.541; 34.1% vs 31.0%, p = 0.523, respectively). There was no significant difference in the recurrence rate and pattern between the LG and OG groups.

CONCLUSIONS:

Laparoscopic gastrectomy is associated with better short-term outcomes and similar long-term outcomes for pT4a Siewert type II/III AEG. This study reveals that LG could be a safe and feasible option for pT4a Siewert type II/III AEG compared to OG.

• Authors: Xia Lin, Jie Wan, Zhengyan Li, Ming Yan, Jiajia Liu, Yan Shi, Feng Qian, Yongliang Zhao
• Journal: Surgical endoscopy (Surg Endosc) Vol. 36 Issue 7 Pg. 5055-5066 (07 2022) ISSN: 1432-2218 [Electronic] Germany
• PMID: 34761283 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Topics

• Adenocarcinoma (pathology, surgery)
• Esophagogastric Junction (pathology, surgery)
• Gastrectomy (methods)
• Humans
• Laparoscopy (methods)
• Propensity Score
• Retrospective Studies
• Serous Membrane
• Stomach Neoplasms (pathology, surgery)
• Treatment Outcome