Abstract | AIMS: METHODS: The study was designed as an open-label, prospective cohort trial with matched controls. In April and May 2021, 51 ICU COVID-19 patients hospitalised in the University Hospital Dubrava and University Hospital Centre Zagreb, Croatia, were treated with fluvoxamine 100 mg three times daily for 15 days in addition to standard therapy and they were prospectively matched for age, gender, vaccination against COVID-19, disease severity and comorbidities with 51 ICU controls. RESULTS: No statistically significant differences between groups were observed regarding the number of days on ventilator support, duration of ICU or total hospital stay. However, overall mortality was lower in the fluvoxamine group, 58.8% (n = 30/51), than in the control group, 76.5% (n = 39/51), HR 0.58, 95% CI (0.36-0.94, P = .027). CONCLUSION:
Fluvoxamine treatment in addition to the standard therapy in hospitalised ICU COVID-19 patients could have a positive impact on patient survival. Further studies on the effects of fluvoxamine in COVID-19 patients are urgently required.
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Authors | Martina Calusic, Robert Marcec, Lea Luksa, Ivan Jurkovic, Natasa Kovac, Slobodan Mihaljevic, Robert Likic |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 88
Issue 5
Pg. 2065-2073
(05 2022)
ISSN: 1365-2125 [Electronic] England |
PMID | 34719789
(Publication Type: Journal Article)
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Copyright | © 2021 British Pharmacological Society. |
Chemical References |
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Topics |
- Fluvoxamine
(adverse effects)
- Humans
- Intensive Care Units
- Prospective Studies
- SARS-CoV-2
- Treatment Outcome
- COVID-19 Drug Treatment
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