Abstract |
Central nervous system (CNS) metastases are rare, but devastating complications of pediatric solid tumors. Radiotherapy alone or postresection serves as an important treatment; however, data on the use of whole-brain radiotherapy (WBRT) versus focal radiotherapy, including stereotactic radiosurgery or stereotactic radiotherapy, for these indications are limited. We report a single institution experience of 26 pediatric patients treated with radiotherapy for solid tumor CNS metastases without leptomeningeal disease. Focal radiotherapy (n = 10) was well tolerated and survival outcomes did not differ between patients treated with WBRT (n = 16) versus focal radiation, suggesting that focal radiotherapy may be considered for patients with limited CNS metastases.
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Authors | Thomas P Howard, Patrick J Boyle, Karen J Marcus, Daphne A Haas-Kogan, Kevin X Liu |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 68
Issue 12
Pg. e29331
(12 2021)
ISSN: 1545-5017 [Electronic] United States |
PMID | 34569132
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2021 Wiley Periodicals LLC. |
Topics |
- Brain Neoplasms
(pathology)
- Central Nervous System
(pathology)
- Child
- Cranial Irradiation
(adverse effects)
- Humans
- Meningeal Neoplasms
- Neoplasms, Second Primary
(etiology)
- Radiosurgery
(adverse effects)
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