Infectious events in kidney transplant recipients from deceased expanded criteria donors: a prospective cohort.

Abstract

OBJECTIVE:

Analyze risk factors for infection in kidney transplant recipients from deceased expanded criteria donors (DECD) in the first two years of follow-up.

METHOD:

This is a prospective cohort study with 466 patients from DECD who underwent kidney transplantation in 2015 and 2016 in Brazil. A total of 551 events were recorded. The largest incidence of infectious events occurred in the first month after kidney transplantation. Cytomegalovirus infection was the most common infectious episode.

RESULTS:

The incidence rate of infections was 57.1%. Among bacterial infections, only 4% were due to multidrug-resistant microorganisms. The death rate was 3.3% (15) patients. The main cause of death was infectious (73.3%). Hospitalization until the first infection (aOR:1.61), Number of infections in 1 year (aOR:40.16), and Cytomegalovirus infection (aOR:13.84) was risk factors for infection by multidrug resistant microorganisms (MDR).

CONCLUSION:

Infection incidence with MDR bacteria was high among kidney transplant recipients from DECD, and the main cause of death was infection. Survival was high among patients with infection.

• Authors: Sirlei Regina de Sousa, Cassiane Dezoti da Fonseca, Monica Taminato, Maria de Fatima Fernandes Vattimo, Angélica Gonçalves Silva Belasco, Álvaro Francisco Lopes de Sousa, Inês Fronteira, Dulce Aparecida Barbosa
• Journal: Revista da Escola de Enfermagem da U S P (Rev Esc Enferm USP) Vol. 55 Pg. e20210255 ( 2021) ISSN: 1980-220X [Electronic] Brazil
• PMID: 34545911 (Publication Type: Journal Article)

Topics

• Cohort Studies
• Humans
• Incidence
• Kidney Transplantation
• Prospective Studies
• Retrospective Studies
• Tissue Donors