Two-dimensional intermetallic PtBi/Pt core/shell nanoplates overcome tumor hypoxia for enhanced cancer therapy.

Abstract

The design of multifunctional nanoplatforms is of great importance for improving hypoxia-induced therapeutic outcomes, especially for overcoming radiotherapy (RT) tolerance. Here, two-dimensional intermetallic PtBi/Pt nanoplates (PtBi NPs) were designed as a therapeutic platform to in situ generate oxygen, and thereby overcome tumor hypoxia for boosting photothermal/radiotherapy (PTT/RT). With high X-ray attenuation coefficient, PtBi NPs exhibited outstanding radiotherapy sensitization characteristics. Moreover, the high photothermal effect of PtBi NPs could promote the catalytic activity of PtBi NPs to achieve a synergistic PTT/RT effect. PEGylated PtBi NPs (PtBi-PEG) exhibited excellent biocompatibility, prolonged blood circulation time and enhanced tumor accumulation. Finally, PtBi-PEG showed excellent trimodal contrast enhancement for infrared (IR) imaging, photoacoustic (PA) imaging and X-ray imaging, facilitating imaging-guided cancer therapy. Thus, our work highlights PtBi-PEG as a novel multifunctional theranostic nanoplatform with great potential for future multimodal imaging-guided synergistic cancer therapy.

• Authors: Yongchun Liu , Xinhao Li , Yu Shi , Youjuan Wang , Xiaojing Zhao , Xiangyang Gong , Ren Cai , Guosheng Song , Mei Chen , Xiaobing Zhang
• Journal: Nanoscale (Nanoscale) Vol. 13 Issue 33 Pg. 14245-14253 (Sep 07 2021) ISSN: 2040-3372 [Electronic] England
• PMID: 34477707 (Publication Type: Journal Article)

Topics

• Humans
• Neoplasms (diagnostic imaging, therapy)
• Photoacoustic Techniques
• Phototherapy
• Theranostic Nanomedicine
• Tumor Hypoxia