Myeloid-derived suppressor cells in obesity-associated periodontal disease: A conceptual model.

Abstract

Periodontitis is a common chronic inflammatory disease characterized by destruction of the supporting structures of the teeth. Severe periodontitis is highly prevalent-affecting 10%-15% of adults-and carries several negative comorbidities, thus reducing quality of life. Although a clear relationship exists between severity of obesity and incidence of periodontal disease, the biologic mechanisms that support this link are incompletely understood. In this conceptual appraisal, a new "two-hit" model is presented to explain obesity-exacerbated periodontal bone loss. This proposed model recognizes a previously unappreciated aspect of myeloid-derived suppressor cell population expansion, differentiation, and activity that can participate directly in periodontal bone loss, providing new mechanistic and translational perspectives.

• Authors: Kyu Hwan Kwack, Victoria Maglaras, Ramkumar Thiyagarajan, Lixia Zhang, Keith L Kirkwood
• Journal: Periodontology 2000 (Periodontol 2000) Vol. 87 Issue 1 Pg. 268-275 (Oct 2021) ISSN: 1600-0757 [Electronic] Denmark
• PMID: 34463977 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Topics

• Humans
• Myeloid-Derived Suppressor Cells
• Obesity (complications)
• Periodontal Diseases (complications)
• Periodontitis (complications)
• Quality of Life