Outcomes and Utilization Trends of Front-Line Autologous Hematopoietic Cell Transplantation for Mantle Cell Lymphoma.

Abstract

Although autologous hematopoietic cell transplantation (auto-HCT) has become a common practice for eligible patients in the front-line setting with mantle cell lymphoma (MCL), there are limited data regarding trends in auto-HCT utilization and associated outcomes. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to evaluate survival outcomes and auto-HCT utilization in adults age ≥18 years who underwent auto-HCT within 12 months of diagnosis of MCL between January 2000 and December 2018. The 19-year period from 2000 to 2018 was divided into 4 separate intervals-2000 to 2004, 2005 to 2009, 2010 to 2014, and 2015 to 2018-and encompassed 5082 patients. To evaluate transplantation utilization patterns, we combined MCL incidence derived from the SEER 21 database with CIBMTR- reported auto-HCT activity within 12 months of diagnosis of MCL. Primary outcomes included overall survival (OS) along with the auto-HCT utilization rate. The cumulative incidence of nonrelapse mortality at 1 year decreased from 7% in the earliest cohort (2000 to 2004) to 2% in the latest cohort (2015 to 2018). Mirroring this trend, OS outcomes improved continually with time, with a 3-year OS of 72% in the earliest cohort improving to 86% in the latest cohort. In addition, we noted an increase in auto-HCT utilization from 2001 to 2018, particularly in patients age ≤65 years. This large retrospective analysis highlights trends in auto-HCT utilization and outcomes in patients with MCL and emphasizes the need to optimize pretransplantation and post-transplantation treatment strategies to enhance survival outcomes.

• Authors: Peter A Riedell, Mehdi Hamadani, Kwang W Ahn, Carlos Litovich, Guru Subramanian Guru Murthy, Frederick L Locke, Claudio G Brunstein, Reid W Merryman, Patrick J Stiff, Attaphol Pawarode, Taiga Nishihori, Mohamed A Kharfan-Dabaja, Alex F Herrera, Craig S Sauter, Sonali M Smith
• Journal: Transplantation and cellular therapy (Transplant Cell Ther) Vol. 27 Issue 11 Pg. 911.e1-911.e7 (11 2021) ISSN: 2666-6367 [Electronic] United States
• PMID: 34450333 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Aged
• Hematopoietic Stem Cell Transplantation
• Humans
• Lymphoma, Mantle-Cell (therapy)
• Retrospective Studies
• Transplantation Conditioning
• Transplantation, Autologous