Abstract | BACKGROUND:
Lymphopenia can decrease immune function of the host and is a known risk factor for poor prognosis in malignant tumors. Radiation induced lymphopenia was common in patients with breast cancer and was also reported to have a negative effect on long-term outcome. AIMS: METHODS: Patients with invasive breast cancer treated from March 2015 to February 2020 and with peripheral lymphocyte counts (PLC) available within 7 days from the beginning of RT were eligible for this study. Data were presented as mean and 95% confidence interval unless otherwise specified. The risk factors of low PLC before RT were identified using univariate and multivariable linear regressions. RESULTS: A total of 1012 consecutive patients met the study criteria. The mean PLC before RT commencement was 1.58*109 /L (95%CI: 1.55-1.62*109 /L) with 15.2% (95%CI: 13.1%-17.6%) CTCAE defined lymphopenia, rendering 12.3%, 2.6%, 0.3%, and 0% for grade 1, 2, 3 and 4 respectively. Univariate and multivariable linear regression showed prior chemotherapy was the most significant risk factor (p < .001) for low PLC, while age, menopausal status and lymph node stage were not (all ps > .05). A total of 912 (90.1%, 95%CI: 88.1%-91.9%) patients had chemotherapy before adjuvant RT in this study. In patients with HR+/HER2- breast cancer, 69.0% (95%CI: 63.0%-74.5%) N0 and 98.1% (95%CI: 95.1%-99.5%) N1 had also received chemotherapy. CONCLUSIONS:
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Authors | Fang Chen, Lingyu Ma, Qian Wang, Manling Zhou, Yaqing Nong, Haiman Jing, Ying Han, Yaya Liu, Yulin Hu, Hao Yu, Pingfu Fu, Feng-Ming Spring Kong |
Journal | Cancer reports (Hoboken, N.J.)
(Cancer Rep (Hoboken))
Vol. 5
Issue 7
Pg. e1525
(07 2022)
ISSN: 2573-8348 [Electronic] United States |
PMID | 34390318
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. |
Topics |
- Breast Neoplasms
(drug therapy)
- Female
- Humans
- Lymphocyte Count
- Lymphopenia
(chemically induced, diagnosis, epidemiology)
- Radiotherapy, Adjuvant
(adverse effects)
- Risk Factors
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