Defeating antibiotic-resistant bacteria with protein-resistant polyGGE film.

Abstract

Biofouling on medical device surfaces, which is initiated by protein adsorption and adhesion of microbes especially the antibiotic-resistant bacteria, attracts global attention for centuries due to its enduring challenges in healthcare. Here, the antifouling effect of hydrophilic poly(glycerol glycidyl ether) (polyGGE) film is explored in comparison to hemocompatible and protein-resistant control polymers. The chemical and thermomechanical stability of polyGGE in hydrated conditions at body temperature was achieved via adjusting UV curing and KOH quenching time. The polyGGE surface is inert to the plasma protein adsorption and interfered the metabolism conditions, biofilm formation and growth of both Gram negative (Gram-) and antibiotic-resistant Gram positive (Gram+) bacteria. These results indicate the potential application of polyGGE for combating the risk of hospital-acquired infections and preventing drug-resistant superbug spreading.

• Authors: Shuo Zhou, Mariagrazia Di Luca, Xun Xu, Nan Ma, Friedrich Jung, Andreas Lendlein
• Journal: Clinical hemorheology and microcirculation (Clin Hemorheol Microcirc) Vol. 79 Issue 4 Pg. 609-623 ( 2021) ISSN: 1875-8622 [Electronic] Netherlands
• PMID: 34366331 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Polymers

Topics

• Adsorption
• Anti-Bacterial Agents (pharmacology)
• Bacteria
• Biofouling
• Polymers