Effects of Preoperative Pyloric Stenosis on Outcomes and Nutritional Status in 73 Patients Following Curative Gastrectomy for Gastric Cancer: A Retrospective Study from a Single Center.

Abstract

BACKGROUND The aim of this study was to explore the potential impact of pyloric stenosis (PS) on the nutritional status, the incidence of postoperative complications, and the long-term prognosis of distal gastric cancer (GC) patients after curative resection. MATERIAL AND METHODS We retrospectively analyzed the data of 343 GC patients who underwent curative gastrectomy for gastric cancer between January 2010 and December 2013. All patients were divided into 2 groups according to the status of PS. Their clinical and pathological features, nutritional indicators, and incidence of postoperative complications were compared and potential prognostic factors were analyzed using the propensity score matching analysis (PSM). RESULTS Seventy-four (21.6%) patients had PS. Patients with PS had worse survival outcomes than those without PS (χ²=21.369, P<0.001). Multivariate survival analysis demonstrated that PS, depth of invasion, and lymph node metastasis (all P<0.05) were the independent predictors of overall survival (OS). Patients with PS had significantly higher lymph node metastasis in No. 3, 4sb, 4d, 6, 8a, 9, and 14v lymph nodes. Patients with PS had significantly lower preoperative BMI, more weight loss, and lower prealbumin than those without PS. There were no significant differences between the 2 groups in postoperative complications, morbidity, or mortality. CONCLUSIONS Distal GC patients with PS have poor clinicopathological and nutritional status and poor prognosis. However, PS does not increase surgery-related morbidity and mortality.

• Authors: Xuguang Jiao, Yu Wang, Xiangyang Qu, Jianjun Qu, Xinbo Wang
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 27 Pg. e930974 (Jul 28 2021) ISSN: 1643-3750 [Electronic] United States
• PMID: 34315845 (Publication Type: Journal Article)

Topics

• Female
• Gastrectomy (methods)
• Humans
• Male
• Middle Aged
• Nutritional Status
• Preoperative Period
• Prognosis
• Propensity Score
• Pyloric Stenosis (complications)
• Retrospective Studies
• Stomach (surgery)
• Stomach Neoplasms (complications, surgery)
• Survival Analysis
• Treatment Outcome