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Transformable upconversion metal-organic frameworks for near-infrared light-programmed chemotherapy.

Abstract
A transformable upconversion MOF comprising a UCNP core and an azobenzene-based MOF shell is designed for NIR light-modulated chemotherapy. The dual Förster resonance energy transfers (FRETs) involved in this delivery system trigger the transformation of the MOF for drug release and prodrug activation, thus significantly inhibiting the tumor growth and metastasis.
AuthorsFang Wang, Zhen Li, Xiaobo Zhang, Rengan Luo, Hanlin Hou, Jianping Lei
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 57 Issue 63 Pg. 7826-7829 (Aug 05 2021) ISSN: 1364-548X [Electronic] England
PMID34278389 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Metal-Organic Frameworks
  • Prodrugs
Topics
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Cell Survival (drug effects)
  • Drug Delivery Systems
  • Drug Screening Assays, Antitumor
  • Female
  • Fluorescence Resonance Energy Transfer
  • Infrared Rays
  • Metal-Organic Frameworks (chemistry)
  • Mice
  • Molecular Structure
  • Particle Size
  • Prodrugs (chemistry, pharmacology)

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