The microwave dynamic
therapy (MDT) mediated by cytotoxic
reactive oxygen species (ROS) is a promising anticancer therapeutic method. However, the therapeutic efficiency of MDT is restricted by several limitations including insufficient ROS generation, strong proangiogenic response, and low
tumor-targeting efficiency. Herein, we find that Cu-based nanoparticles can produce
oxygen under microwave (MW) irradiation to raise the generation of ROS, such as •O2, •OH and 1O2, especially •O2. On this basis, a nanoengineered biomimetic strategy is designed to improve the efficiency of MDT. After
intravenous administration, the nanoparticles accumulate to the
tumor site through targeting effect mediated by biomimetic modification, and it can continuously produce
oxygen to raise the levels of ROS in tumor microenvironment under MW irradiation for MDT. Additionally,
Apatinib is incorporated as antiangiogenic drug to downregulate the expression of
vascular endothelial growth factor (
VEGF), which can effectively inhibit the
tumor angiogenesis after MDT. Hence, the
tumor inhibition rate is as high as 96.79%. This study provides emerging strategies to develop multifunctional nanosystems for efficient
tumor therapy by MDT.