[Three Cases of Colon Medullary Carcinoma in Our Institution].

Abstract

Medullary carcinoma of the colorectum is a relatively new histological subtype that was first described in the eighth edition of the Japanese classification of colorectal, appendiceal, and anal carcinoma. In our institution, only 3 cases of medullary carcinoma have been diagnosed since 2013. Case #1 was a 93-year-old woman with type 1 ascending colon cancer; she received a right hemicolectomy. The tumor invaded the subserosal layer, but no lymph nodal metastasis was observed. Case #2 was a 91-year-old woman with obstructive ascending colon cancer. After intracolonic decompression using the transnasal ileus tube, she received a right hemicolectomy. This tumor also extended into the subserosal layer without lymph nodal metastasis. Case #3 was a 65-year-old woman with a family history of cancers; she received a right hemicolectomy for cecal cancer with an aberrant elevation of serum tumor markers such as CEA and CA19-9. The tumor invaded the subserosal layer with regional lymph nodal metastases. Notably, these 3 cases were females who had right-sided tumors and all showed diminished expressions of MLH1 and PMS2 mismatch repair-associated genes, together with epidemiological characteristics of medullary carcinoma. Herein, we report their pathological features along with the corresponding literature review.

• Authors: Yumiko Morimoto, Munenori Takaoka, Yasumasa Monobe, Naomasa Ishida, Minoru Haisa, Masaki Matsubara, Jiro Hayashi, Kazuhiro Yoshida, Atsushi Urakami, Tomoki Yamatsuji
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 48 Issue 7 Pg. 967-969 (Jul 2021) ISSN: 0385-0684 [Print] Japan
• PMID: 34267038 (Publication Type: Case Reports, Journal Article)

Topics

• Adenocarcinoma
• Aged
• Aged, 80 and over
• Carcinoma, Medullary
• Colonic Neoplasms (surgery)
• DNA Mismatch Repair
• Female
• Humans