131I-radioisotope modified in PEGylation metal organic frameworks for sensitization in refractory differentiated thyroid cancer treatment.

Abstract

Radiation therapy for cancer can lead to off-target toxicity and can be ineffective against refractory differentiated thyroid cancer. The nanoscale metal organic frameworks (NMOFs) have shown great potential in cancer diagnostic and treatment due to their advantages in the aspect of structural diversities, high intrinsic biodegradability and drug-loading capacities. Here, we provide that intratumoral injection, in mouse of refractory differentiated thyroid cancer.In this work, we used the therapeutic 131I radioisotope modified Zr-MOF (Zr-MOF@131I) with aim to enable long-term relief of tumour therapy, which has successfully eliminated tumour at ralatively low radioactivity doses. Polyethylene glycol (PEG) was coated into Zr-MOF and, as a result, circulation time was significantly improved by intratumoral injection. These findings therefore suggest that nanoparticles could be used in vivo combined therapy. On injection, while it is a highly effective drug for radioisotope, Zr-MOF with attenuation ability could apply for a radio-sensitizer to enhance inner radiotherapy (RT). The local therapy, which uses only biocompatible components, might enable new strategies for local tumour treatments. These could be further combined with systemic therapeutic responses for the inhibition of refractory differentiated thyroid cancer and the prevention of tumour recurrence in patients.

• Authors: Shuai Jiang, Miao Yu, Haoyang Wang, Songqi Han, Mengfei Cheng, Shuo Zhang, Jiahui Liu, Xinghua Wang, Mei Dong
• Journal: Journal of biomaterials applications (J Biomater Appl) Vol. 36 Issue 5 Pg. 851-858 (11 2021) ISSN: 1530-8022 [Electronic] England
• PMID: 34254840 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodine Radioisotopes
• Iodine-131
• Metal-Organic Frameworks
• Radiation-Sensitizing Agents
• Polyethylene Glycols

Topics

• Animals
• Cell Line, Tumor
• Cell Survival (drug effects)
• Disease Models, Animal
• Humans
• Iodine Radioisotopes (chemistry, pharmacology)
• Metal-Organic Frameworks (chemistry, pharmacology)
• Mice
• Mice, Inbred BALB C
• Nanoparticles
• Polyethylene Glycols (chemistry, pharmacology)
• Radiation-Sensitizing Agents
• Thyroid Neoplasms (drug therapy)