Background:
CircRNA plays an important role in
cancer progression. However, the potential mechanism of
circRNA in
gastric cancer remains unknown. In this study, we aimed to investigate the specific mechanism of circALPL in
gastric cancer. Methods: Using a high-throughput microarray, we found that circALPL was upregulated in
gastric cancer cell lines. RT-qPCR was used to measure the circALPL expression level in gastric cell lines and tissue. Transwell,
CCK-8, and
metastasis assays were performed to learn the function after circALPL was inhibited. Results: circALPL downregulation suppresses the invasion and proliferation ability of
gastric cancer cells. Additionally, the underlying pathway of circALPL was studied using
luciferase reporter assays and
RNA immunoprecipitation assays. The results showed that circALPL promotes
gastric cancer progression by sponging miR-127, thus upregulating MTDH. Conclusion: The circALPL-miR-127-MTDH pathway plays a vital role in
gastric cancer proliferation and
metastasis. circALPL might be a new therapeutic target in
gastric cancer.