Abstract | BACKGROUND: METHODS: We retrospectively investigated patients with peritoneal metastases from CRC treated with curative intent surgery with or without hyperthermic intraperitoneal chemotherapy at 13 institutions worldwide between January 1985 and April 2015 and survived longer than five years after the first CRS for peritoneal metastases. Clinical and oncological features and therapeutic parameters were described and analyzed. RESULTS: Two hundred six long-term survivors were available for study. The median peritoneal cancer index (PCI) of this cohort was 4 (interquartile range (IQR), 2-7), and the median score of the small bowel regions of the PCI (SB-PCI) was 0 (IQR, 0-2). Complete cytoreduction (CC-0) was achieved in 180 (87.4%) patients. Recurrence was observed in 122 (59.2%) patients at a median of 1.8 (IQR, 1.2-2.6) years. CONCLUSIONS: While most long-term survivors showed low PCI/SB-PCI and CCR-0, some had characteristics considered associated with poor prognosis. Curative intent treatments may be considered in well-informed and fit patients showing negative factors affecting survival outcome.
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Authors | Yasuyuki Kamada, Koya Hida, Yutaka Yonemura, Paul H Sugarbaker, Shadin Ghabra, Soichiro Ishihara, Hiroshi Nagata, Koji Murono, Takanori Goi, Kanji Katayama, Mitsuhiro Morikawa, Beate Rau, Pompiliu Piso, Miklos Acs, Federico Coccolini, Emel Canbay, Mao-Chih Hsieh, Aditi Bhatt, Pierre-Emmanuel Bonnot, Olivier Glehen |
Journal | Cancers
(Cancers (Basel))
Vol. 13
Issue 12
(Jun 13 2021)
ISSN: 2072-6694 [Print] Switzerland |
PMID | 34199234
(Publication Type: Journal Article)
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