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Water-stable zirconium-based metal-organic frameworks armed polyvinyl alcohol nanofibrous membrane with enhanced antibacterial therapy for wound healing.

Abstract
Inadequate water-stability and antibacterial activity limit the biomedical application of polyvinyl alcohol (PVA)-based membranes in moist environments. In this work, we propose a strategy to improve the water-stability of PVA membranes via metal complexation and heat treatment. We report a simple routine where the zirconium-based UiO-66-NH2 metal-organic frameworks (MOFs) are nucleated as a layer on the surface of PVA nanofibrous membranes (UiO-66-NH2@PVA NFMs). We find that the chemical modification of membranes increases their hydrophilicity and adds on mechanical support for the brittle UiO-66-NH2 MOFs. Additionally, we demonstrate the application of UiO-66-NH2 MOFs as drug carriers for antibacterial drug, levofloxacin (LV). The active drug component is preloaded during the one-step nucleation process. The obtained LV loaded UiO-66-NH2@PVA NFMs (LV@UiO-66-NH2@PVA) are shown to be bactericidal with the efficiency > 99.9% at 100 μg/mL against two bacterial species, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available gauzes, the UiO-66-NH2@PVA and LV@UiO-66-NH2@PVA treatments will significantly improve the wound healing process. Animal studies show that the LV@UiO-66-NH2@PVA will effectively offer a safe alternative solution for the patients to protect against bacterial infections, demonstrating the potential application of MOF-based NFMs as wound dressing agents.
AuthorsJie Zhu, Weiwang Qiu, Chengjian Yao, Chun Wang, Dequn Wu, Shravan Pradeep, Jianyong Yu, Zijian Dai
JournalJournal of colloid and interface science (J Colloid Interface Sci) Vol. 603 Pg. 243-251 (Dec 2021) ISSN: 1095-7103 [Electronic] United States
PMID34186401 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier Inc. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Metal-Organic Frameworks
  • Water
  • Polyvinyl Alcohol
  • Zirconium
Topics
  • Animals
  • Anti-Bacterial Agents (pharmacology)
  • Escherichia coli
  • Humans
  • Metal-Organic Frameworks
  • Nanofibers
  • Polyvinyl Alcohol
  • Staphylococcus aureus
  • Water
  • Wound Healing
  • Zirconium

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