Abstract | PURPOSE: METHODS AND MATERIALS: Patients with LANSCLC were considered eligible if their forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC%) and carbon monoxide diffusing capacity (DLCO%) were ≥40% and ≥45%, respectively. HRT-CHT using the intensity modulated radiation therapy technique was administered with 51 Gy in 17 fractions as the first course followed by a break. Patients without disease progression or persistent ≥grade 2 toxicities had an HRT-CHT of 15 to 18 Gy in 5 to 6 fractions as a boost. The primary endpoint was progression-free survival, and the secondary endpoint was overall survival (OS). RESULTS: Eighty-nine patients were enrolled and analyzed. The median follow-up was 29.5 months for all patients and 35.3 months for the survivors. The objective response rate was 97.8%; the median progression-free survival and OS were 11.0 and 27.0 months, respectively. Grade 3 acute esophagitis/ pneumonitis occurred in 15 (16.9%)/7 (7.9%) patients. Grade 3/5 late pneumonitis occurred in 2 (2.2%)/1 (1.1%) patients. Of the 78 (87.6%) who completed the split-course HRT-CHT per protocol, patients with better FEV1/FVC% and DLCO% after the break had significantly better OS (for the FEV/FVC1% ≥ 80% vs 60%-79% vs 41%-59% groups, 2-year OS values were 57.2% vs 56.9% vs 0%, respectively, P = .024; for the DLCO% ≥ 80% vs 60%-79% vs 45%-59% groups, 2-year OS values were 70.4% vs 48.4% vs 37.5%, respectively, P = .049). CONCLUSIONS: Split-course HRT-CHT achieved a promising response rate and survival with tolerable toxicity in LANSCLC. Pulmonary function tests are necessary indicators for radiation treatment planning and dose escalation.
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Authors | Bo Qiu, Mai Xiong, YiFeng Luo, QiWen Li, NaiBin Chen, Li Chen, SuPing Guo, Bin Wang, XiaoYan Huang, MaoSheng Lin, Nan Hu, JinYu Guo, Ying Liang, Yi Fang, JiBin Li, YunPeng Yang, Yan Huang, Li Zhang, SiYu Wang, Hui Liu |
Journal | Practical radiation oncology
(Pract Radiat Oncol)
2021 Sep-Oct
Vol. 11
Issue 5
Pg. 374-383
ISSN: 1879-8519 [Electronic] United States |
PMID | 34157448
(Publication Type: Clinical Trial, Phase II, Journal Article)
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Copyright | Copyright © 2021. Published by Elsevier Inc. |
Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, radiotherapy)
- Humans
- Lung Neoplasms
(drug therapy, radiotherapy)
- Prospective Studies
- Radiotherapy, Intensity-Modulated
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