[A Case of Advanced Gastric Cancer with Para-Aortic Lymph Node Metastasis with Long-Term Survival by Chemotherapy and Surgery].

Abstract

Chemotherapy is the standard treatment for unresectable gastric cancer, but there is no clear evidence of therapeutic lymphadenectomy in conversion surgery after the tumor shrinks or the combined effect of perioperative chemotherapy. A 63-year-old man was diagnosed with advanced gastric cancer by upper gastrointestinal endoscopy; computed tomography (CT)showed swelling of the gastric regional lymph nodes, abdominal para-aortic lymph nodes, and left supraclavicular lymph node. After 4 courses of combination therapy with S-1 and cisplatin(SP therapy), CT showed that the left supraclavicular lymph node disappeared and the para-aortic lymph node was reduced. Distal gastrectomy and D2 plus para-aortic lymph node dissection were performed as conversion surgery. Two courses of postoperative SP therapy were administered, and S-1 monotherapy was continued for 2 years and 6 months. After 5 years and 1 month since the operation, the patient is alive without recurrence. This case shows that SP therapy can be effective as chemotherapy for unresectable gastric cancer. In addition, that conversion surgery after chemotherapy may contribute to recurrence-free survival.

• Authors: Takayuki Sano, Tatsuo Ichikawa, Akira Iai, Kiyoshi Osa, Takeshi Inoue, Satoshi Ono, Kouzo Asanuma, Shiori Kaneko, Tadao Kuribara, Itaru Shigeyoshi, Kouta Matsubara, Naoko Irie, Hideki Ishizu
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 48 Issue 6 Pg. 825-827 (Jun 2021) ISSN: 0385-0684 [Print] Japan
• PMID: 34139732 (Publication Type: Case Reports, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Gastrectomy
• Humans
• Lymph Node Excision
• Lymph Nodes
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Recurrence, Local
• Stomach Neoplasms (drug therapy, surgery)