Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways.

Abstract

This study aimed to evaluate the acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory and cAMP response element binding (CREB)-related pathways. A total of 120 male Wistar rats were divided into four groups: a control group (C); 2.856 GHz microwave exposure group (S group); 1.5 GHz microwave exposure group (L group); and 2.856 and 1.5 GHz cumulative exposure group (SL group). Decreases in spatial memory abilities, changes in EEG, structural injuries, and the downregulation of phosphorylated-Ak strain transforming (p-AKT), phosphorylated-calcium/calmodulin-dependent protein kinase II (p-CaMKII), phosphorylated extracellular signal regulated kinase (p-ERK) and p-CREB was observed 6 h after microwave exposure. Significant differences in the expression of p-CaMKII were found between the S and L groups. The power amplitudes of the EEG waves (θ, δ), levels of structural injuries and the expression of p-AKT, p-CaMK II, p-CREB, and p-ERK1/2 were significantly different in the S and L groups compared to the SL group. Interaction effects between the 2.856 and 1.5 GHz microwaves were found in the EEG and p-CREB changes. Our findings indicated that 2.856 GHz and 1.5 GHz microwave exposure induced a decline in spatial memory, which might be related to p-AKT, p-CaMK II, p-CREB and p-ERK1/2.

• Authors: Shengzhi Tan, Hui Wang, Xinping Xu, Li Zhao, Jing Zhang, Ji Dong, Binwei Yao, Haoyu Wang, Yanhui Hao, Hongmei Zhou, Yabing Gao, Ruiyun Peng
• Journal: Scientific reports (Sci Rep) Vol. 11 Issue 1 Pg. 12348 (06 11 2021) ISSN: 2045-2322 [Electronic] England
• PMID: 34117282 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Creb1 protein, rat
• Cyclic AMP Response Element-Binding Protein
• Proto-Oncogene Proteins c-akt
• Calcium-Calmodulin-Dependent Protein Kinase Type 2
• Extracellular Signal-Regulated MAP Kinases

Topics

• Animals
• Calcium-Calmodulin-Dependent Protein Kinase Type 2 (metabolism)
• Cyclic AMP Response Element-Binding Protein (metabolism)
• Delta Rhythm
• Extracellular Signal-Regulated MAP Kinases (metabolism)
• Hippocampus (metabolism, physiology, radiation effects)
• Male
• Microwaves (adverse effects)
• Proto-Oncogene Proteins c-akt (metabolism)
• Rats
• Rats, Wistar
• Spatial Memory
• Theta Rhythm