Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test.

Abstract

OBJECTIVE:

Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy.

METHODS:

We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test.

RESULTS:

Although rats with pilocarpine-induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials.

SIGNIFICANCE:

Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE.

• Authors: Mariana Bocca Nejm, Daniella Balduino Victorino, Marcia Jonathas Guimarães-Marques, Carla Alessandra Scorza, Josef Finsterer, Fulvio Alexandre Scorza, Roberta Monterazzo Cysneiros
• Journal: Epileptic disorders : international epilepsy journal with videotape (Epileptic Disord) Vol. 23 Issue 3 Pg. 476-484 (Jun 01 2021) ISSN: 1950-6945 [Electronic] United States
• PMID: 34080984 (Publication Type: Journal Article)

Chemical References

• Fish Oils
• Pilocarpine

Topics

• Animals
• Dietary Supplements
• Epilepsy
• Epilepsy, Temporal Lobe (chemically induced, drug therapy)
• Fish Oils (pharmacology)
• Morris Water Maze Test
• Pilocarpine (toxicity)
• Rats
• Spatial Memory