Because of the deficiency of lymphatic reflux in the
tumor, the retention of
tumor interstitial fluid causes aggravation of the
tumor interstitial pressure (TIP), which leads to unsatisfactory
tumor penetration of nanomedicine. It is the main inducement of
tumor recurrence and
metastasis. Herein, we design a pyroelectric catalysis-based "Nano-lymphatic" to decrease the TIP for enhanced
tumor penetration and treatments. It realizes
photothermal therapy and decomposition of
tumor interstitial fluid under NIR-II
laser irradiation after reaching the
tumor, which reduces the TIP for enhanced
tumor penetration. Simultaneously,
reactive oxygen species generated during the pyroelectric catalysis can further damage deep tumor stem cells. The results indicate that the "Nano-lymphatic" relieves 52% of TIP, leading to enhanced
tumor penetration, which effectively inhibits the
tumor proliferation (93.75%) and recurrence. Our finding presents a rational strategy to reduce TIP by pyroelectric catalysis for enhanced
tumor penetration and improved treatments, which is of great significance for drug delivery.