Correlation between circulating blood and microenvironment T lymphocytes in diffuse large B-cell lymphomas.

Abstract

AIMS:

Diffuse large B-cell lymphoma (DLBCL) is characterised by marked clinical and biological heterogeneity, attributable to the tumour cells and their microenvironment.

METHODS:

In this study, we investigated circulating subsets of blood lymphocytes and monocytes and their relationship with T cells in the tumour microenvironment (TME) in chemoresistant and chemosensitive patients with DLBCL.

RESULTS:

The study showed that (1) absolute lymphocyte count (ALC) and CD3+ and CD4+ cells were reduced in chemoresistant patients compared with chemosensitive patients; (2) lymphocyte:monocyte ratio (LMR) showed a positive correlation with peripheral blood CD3+ and CD4+ cells; (3) ALC, LMR, peripheral blood CD3+ and CD4+ cells showed a positive correlation with T cells in the TME.

CONCLUSIONS:

Overall, these data suggest that DLBCL with high TME T cells display a pre-existing antitumour immune response. In the rituximab-containing regimen, TME T cells are stimulated further to participate in the immune response against lymphoma cells. In contrast, DLBCL lymphomas with low T-cell infiltration reflect the absence of a pre-existing antitumour immunity and have a lower likelihood of obtaining an optimal response to therapy.

• Authors: Filomena Emanuela Laddaga, Giuseppe Ingravallo, Anna Mestice, Roberto Tamma, Tommasina Perrone, Eugenio Maiorano, Domenico Ribatti, Giorgina Specchia, Francesco Gaudio
• Journal: Journal of clinical pathology (J Clin Pathol) Vol. 75 Issue 7 Pg. 493-497 (Jul 2022) ISSN: 1472-4146 [Electronic] England
• PMID: 34011621 (Publication Type: Journal Article)
• Copyright: © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Topics

• Humans
• Lymphocyte Count
• Lymphocytes (pathology)
• Lymphoma, Large B-Cell, Diffuse (pathology)
• Monocytes (pathology)
• Prognosis
• Tumor Microenvironment