Immune-checkpoint inhibition in stage III unresectable NSCLC: Challenges and opportunities in the post-PACIFIC era.

Abstract

The PACIFIC trial marked a new era in the treatment of stage III unresectable NSCLC, establishing durvalumab consolidation as new standard of care worldwide, with about 14 % increase of long-term survival and half of the patients alive at 4 years. A series of intensified immune-checkpoint inhibition regimens are currently under investigation in clinical trials in order to optimize the therapeutic benefit obtained in this population, while the identification of personalized approaches as well as the development of effective treatments in the post-durvalumab progression setting represent an actual and controversial topic for clinical lung cancer research. This review describes the current real-word treatment scenario for stage III unresectable NSCLC in Italy, and provides an updated overview of the upcoming therapeutic strategies under clinical investigation, discussing the most relevant challenges and opportunities featuring the post-PACIFIC era.

• Authors: Francesco Passiglia, Gianmarco Leone, Emanuela Olmetto, Marco Donatello Delcuratolo, Fabrizio Tabbò, Maria Lucia Reale, Valentina Bertaglia, Lorena Consito, Paolo Bironzo, Enrica Capelletto, Silvia Novello
• Journal: Lung cancer (Amsterdam, Netherlands) (Lung Cancer) Vol. 157 Pg. 85-91 (07 2021) ISSN: 1872-8332 [Electronic] Ireland
• PMID: 33994198 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021. Published by Elsevier B.V.

Chemical References

• Antineoplastic Agents, Immunological
• Immune Checkpoint Inhibitors

Topics

• Antineoplastic Agents, Immunological (therapeutic use)
• Chemoradiotherapy
• Humans
• Immune Checkpoint Inhibitors
• Italy
• Lung Neoplasms (drug therapy)