PEGylated AIEgen molecular probe for hypoxia-mediated tumor imaging and photodynamic therapy.

Abstract

We report a novel PEGylated aggregation-induced emission luminogen (AIEgen) molecular probe for hypoxia-mediated tumor imaging and photodynamic therapy by linking a PEG chain to the AIE-active photosensitizer via a hypoxia-sensitive azo group.

• Authors: Jun Li, Wei Liu, Zuhao Li, Yingcai Hu, Jinfeng Yang, Jishan Li
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 57 Issue 38 Pg. 4710-4713 (May 11 2021) ISSN: 1364-548X [Electronic] England
• PMID: 33977996 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Fluorescent Dyes
• Photosensitizing Agents
• Polyethylene Glycols

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology)
• Cell Proliferation (drug effects)
• Density Functional Theory
• Drug Screening Assays, Antitumor
• Fluorescent Dyes (chemistry, pharmacology)
• Hep G2 Cells
• Humans
• Hypoxia (drug therapy)
• Liver Neoplasms, Experimental (diagnostic imaging, drug therapy)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Molecular Structure
• Optical Imaging
• Photosensitizing Agents (chemistry, pharmacology)
• Polyethylene Glycols (chemistry, pharmacology)