Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease.

Abstract

A massively enlarged kidney can impact quality of life of autosomal dominant polycystic kidney disease (ADPKD) patients. A recent in vitro study demonstrated that an allosteric modulator of the calcium sensing receptor decreases adenosine-3',5'-cyclic monophosphate, an important factor for kidney enlargement in ADPKD. Therefore, the present study was performed to determine whether cinacalcet, a calcium sensing receptor agonist, suppresses kidney enlargement in hemodialysis patients with ADPKD. Alteration of total kidney volume together with clinical parameters was retrospectively examined in 12 hemodialysis patients with ADPKD treated at a single institution in Japan. In the non-cinacalcet group with longer hemodialysis duration (n = 5), total kidney volume had an annual increase of 4.19 ± 1.71% during an overall period of 877 ± 494 days. In contrast, the annual rate of increase in total kidney volume in the cinacalcet group (n = 7) was significantly suppressed after cinacalcet treatment, from 3.26 ± 2.87% during a period of 734 ± 352 days before the start of cinacalcet to - 4.71 ± 6.42% during 918 ± 524 days after initiation of treatment (p = 0.047). The present findings showed that cinacalcet could be a novel therapeutic tool for suppression of kidney enlargement in hemodialysis patients with ADPKD.

• Authors: Shinya Nakatani, Kozo Nishide, Senji Okuno, Eiji Ishimura, Daijiro Kabata, Fumiyuki Morioka, Yuri Machiba, Hideki Uedono, Akihiro Tsuda, Shigeichi Shoji, Masaaki Inaba, Katsuhito Mori, Tomoyuki Yamakawa, Masanori Emoto
• Journal: Scientific reports (Sci Rep) Vol. 11 Issue 1 Pg. 10014 (05 11 2021) ISSN: 2045-2322 [Electronic] England
• PMID: 33976330 (Publication Type: Journal Article, Observational Study)

Chemical References

• Calcium-Regulating Hormones and Agents
• Parathyroid Hormone
• Phosphates
• Calcium
• Cinacalcet

Topics

• Aged
• Calcium (blood)
• Calcium-Regulating Hormones and Agents (pharmacology, therapeutic use)
• Cinacalcet (pharmacology, therapeutic use)
• Female
• Humans
• Hypertrophy (etiology, prevention & control)
• Kidney (drug effects, pathology)
• Kidney Failure, Chronic (blood, complications, drug therapy, pathology)
• Male
• Middle Aged
• Organ Size (drug effects)
• Parathyroid Hormone (blood)
• Phosphates (blood)
• Polycystic Kidney, Autosomal Dominant (blood, complications, drug therapy, pathology)
• Retrospective Studies