Abstract |
Quantitative magnetic resonance imaging (MRI) has been used for the in vivo size determination of subcutaneously implanted Dunning R3327-H tumors in male Copenhagen-Fisher rats (N = 18). Images have been recorded using a multislice spin-echo sequence SE(1000/36) with a resolution of 0.2 x 0.2 mm2 in the imaging plane and a slice thickness of 2 mm. The reliability in the MRI size determination was of the order of 10%. The MRI results were compared with caliper measurements. Five months after tumor implantation nine rats were castrated. Orchiectomy led to a marked and statistically significant reduction in tumor growth rate as determined by both methods of quantification. Qualitative MRI information regarding the tumor morphology was compared with that for histological specimens.
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Authors | M Rudin, S Qureshi, L Tolcsvai, R A Siegel |
Journal | The Prostate
(Prostate)
Vol. 12
Issue 4
Pg. 333-41
( 1988)
ISSN: 0270-4137 [Print] United States |
PMID | 3393495
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adenocarcinoma
(diagnosis, pathology)
- Animals
- Magnetic Resonance Imaging
(methods)
- Male
- Neoplasm Transplantation
- Orchiectomy
- Prostatic Neoplasms
(diagnosis, pathology)
- Rats
- Rats, Inbred F344
- Time Factors
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