Wrapping double-mattress anastomosis for pancreaticojejunostomy in minimally invasive pancreaticoduodenectomy can significantly reduce postoperative pancreatic fistula rate compared with conventional pancreaticojejunostomy in open surgery: An analysis of a propensity score-matched sample.

Abstract

BACKGROUND:

Minimally invasive pancreaticoduodenectomy (MIPD), including laparoscopic pancreaticoduodenectomy (LPD) and robotic pancreaticoduodenectomy (RPD), is technically demanding because of pancreaticojejunostomy (PJ). Postoperative pancreatic fistula (POPF) is the most serious complication of MIPD and open pancreaticoduodenectomy (OPD). Contrary to expectations, conventional PJ in MIPD did not improve POPF rate and length of hospital stay. High POPF rates are attributed to technical issues encountered during MIPD, which include motion restriction and insufficient water tightness. Therefore, we developed wrapping double-mattress anastomosis, the Kiguchi method, which is a novel PJ technique that can improve MIPD. Herein, we describe the Kiguchi method for PJ in MIPD and compare the outcomes between this technique and conventional PJ in OPD.

METHODS:

The current retrospective study included 83 patients in whom the complete obstruction of the main pancreatic duct by pancreatic tumors was absent on preoperative imaging. This research was performed from September 2016 to August 2020 at Fujita Health University Hospital. All patients were evaluated as having a soft pancreatic texture, which is the most important factor associated with POPF development. Briefly, 50 patients underwent OPD with conventional PJ (OPD group). Meanwhile, 33 patients, including 15 and 18 who had LPD and RPD, respectively, underwent MIPD using the Kiguchi method (MIPD group). After a 1:1 propensity score matching, 30 patients in the OPD group were matched to 30 patients in the MIPD group.

RESULTS:

The patients' preoperative data did not differ. The grade B/C POPF rate was significantly lower in the MIPD group than in the OPD group (6.7% vs 40.0%, p = 0.002). The MIPD group had a significantly shorter median length of hospital stay than the OPD group (24 vs 30 days, p = 0.004).

CONCLUSION:

The novel Kiguchi method in MIPD significantly reduced the POPF rate in patients without complete obstruction of the main pancreatic duct.

• Authors: Gozo Kiguchi, Atsushi Sugioka, Yuichiro Uchida, Junichi Yoshikawa, Masaya Nakauchi, Masayuki Kojima, Yoshinao Tanahashi, Takeshi Takahara, Akira Yasuda, Koichi Suda, Yutaro Kato, Ichiro Uyama
• Journal: Surgical oncology (Surg Oncol) Vol. 38 Pg. 101577 (Sep 2021) ISSN: 1879-3320 [Electronic] Netherlands
• PMID: 33887674 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Anastomosis, Surgical (methods)
• Female
• Humans
• Laparoscopy
• Length of Stay
• Male
• Matched-Pair Analysis
• Middle Aged
• Pancreatic Fistula (prevention & control)
• Pancreatic Neoplasms (surgery)
• Pancreaticoduodenectomy
• Pancreaticojejunostomy
• Postoperative Complications (prevention & control)
• Propensity Score
• Retrospective Studies