The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report.

Abstract

BACKGROUND:

Native valves infective endocarditis due to Escherichia coli is still a rare disease and a particular virulence of some E.coli isolate may be suspected.

CASE PRESENTATION:

A 79-year-old woman presented during the post-operative period of an orthopedic surgery a urinary tract infection following obstructive ureteral lithiasis. E. coli was isolated from a pure culture of urine and blood sampled simultaneously. After evidence of sustained E.coli septicemia, further investigations revealed acute cholecystitis with the same micro-organism in biliary drainage and a native valve mitral endocarditis. E.coli was identified as O2:K7:H6, phylogenetic group B2, ST141, and presented several putative and proven virulence genes. The present isolate can be classified as both extra-intestinal pathogenic E.coli (ExPECJJ) and uropathogenic E. coli (UPECHM).

CONCLUSIONS:

The relationship between the virulent factors present in ExPEC strains and some serotypes of E. coli that could facilitate the adherence to cardiac valves warrants further investigation.

• Authors: Marie-Françoise Leonard, Hector Rodriguez-Villalobos, Nadia Boisen, Flemming Scheutz, Pierre-François Laterre, Philippe Hantson
• Journal: BMC infectious diseases (BMC Infect Dis) Vol. 21 Issue 1 Pg. 370 (Apr 20 2021) ISSN: 1471-2334 [Electronic] England
• PMID: 33879083 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Animals
• Endocarditis (diagnosis, microbiology)
• Extraintestinal Pathogenic Escherichia coli (classification, isolation & purification, pathogenicity)
• Female
• Humans
• Orthopedic Procedures (adverse effects)
• Phylogeny
• Postoperative Period
• Urinary Tract Infections (microbiology, pathology)
• Urolithiasis (surgery)
• Virulence (genetics)